Jota signed a long-term contract with Liverpool on September 19, 2020. Five days later, he made his EFL Cup debut, coming on as a second-half substitute in a 7-2 triumph over Lincoln City. On September 28, he made his Premier League debut for the club, scoring the third goal in a 3-1 win over Arsenal at Anfield.

On October 25, he scored the game-winning goal against Sheffield United at Anfield. Jota finished his debut season with nine league goals.

He renewed his contract with the club in August 2022, ahead of the start of the next season, before making his 100th appearance.